New research suggests that patients who stop using blockbuster slimming jabs like semaglutide or tirzepatide may regain shed pounds much more quickly than those who stop traditional diet and exercise regimens.
Research printed in a prominent health publication shows that while overweight individuals can lose substantial amounts of their total mass while undergoing treatment, the weight is regained at an average rate of nearly a kilo each month after stopping.
"People using these treatments need to be cognizant of the risk of fast weight regain when the medication is stopped," warns researcher Dr. Susan Jebb.
Such speed of recovery suggests a return to original weight within about 18 months.
Analyzing Approaches
The study, which reviewed 37 of studies involving over 9,000 of participants, contrasted the effects of GLP-1 agonists with conventional dieting.
Scientists note that people who lose weight through lifestyle changes alone generally experience a less rapid weight regain—approximately 100 grams monthly—once they finish.
Understanding the Fast Rebound
Experts believe the mechanism of the injections accounts for the heightened weight return.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate appetite.
"Long-term administration of the hormone levels far above than normal could lead to the system to generate a reduced amount of its endogenous hormone, and could reduce sensitivity to its actions," explained Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this hormone supplement results in appetite is no longer kept in check, making overeating a significant risk."
An Ongoing Condition?
Health authorities recommend the injections for people with obesity-related health risks, accompanied by recommended diet and exercise modifications.
Many experts contend that, given the high risk of weight regain, the treatment is often long-term.
This view is echoed by drug manufacturers, who say that the findings "underscore the chronic character of excess weight," comparing it to managing diseases like diabetes.
Patient Testimonies
Users who have stopped the medication report a sudden resurgence of appetite.
"It was like something activating and you become starving," recalled an individual.
This challenge is compounded if patients have not developed permanent lifestyle or habit changes during treatment.
Significant Use
Survey data show that a significant number of people in the UK have tried these injections in the last 12 months, with demand remaining high.
- Use is higher among women compared to men.
- The middle-aged demographic shows the highest usage rates.
- Many obtain the medications through private healthcare rather than public health services.
In conclusion, clinicians stress that while these medications are powerful tools for shedding pounds, they are not a permanent fix and long-term success hinges on ongoing behavioural support.
